Tackling both sides of the host-pathogen equation with Caenorhabditis elegans.
نویسنده
چکیده
If one is interested in dissecting the complex interactions that exist between host and pathogen, the nematode worm Caenorhabditis elegans is perhaps not the first model host that comes to mind. In this review I will introduce 'the worm' and try to show how it is, in fact, well suited to the identification of universal virulence factors and holds great promise for the study of conserved mechanisms of innate immunity.
منابع مشابه
Caenorhabditis elegans as a host for the study of host-pathogen interactions.
Recently, pathogenicity models that involve the killing of the genetically tractable nematode Caenorhabditis elegans by human pathogens have been developed. From the perspective of the pathogen, the advantage of these models is that thousands of mutagenized bacterial clones can be individually screened for avirulent mutants on separate petri plates seeded with C. elegans. The advantages of usin...
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The genetic analysis of mechanisms of pathogen resistance in the nematode Caenorhabditis elegans has revealed a role for evolutionarily conserved signaling pathways that are required for innate immunity in a wide range of organisms, from worms to mammals. C. elegans represents one of the more simple host organisms in which mechanisms of host defense can be dissected, and the use of C. elegans p...
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The nematode Caenorhabditis elegans is proving to be a powerful invertebrate model to study host-pathogen interactions. In common with other invertebrates, C. elegans relies solely on its innate immune system to defend itself against pathogens. Studies of the nematode response to infection with various fungal and bacterial pathogens have revealed that the innate immune system of C. elegans empl...
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Background The nematode Caenorhabditis elegans is one of the popular model hosts for the study of the evolutionarily conserved mechanism of microbial pathogenesis and innate immunity. C. elegans can be effectively used to study the dynamics of polymicrobial infections. Proteus mirabilis, an opportunistic pathogen, does not cause death in C. elegans. In this study the C. elegans was pre-infected...
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ورودعنوان ژورنال:
- Microbes and infection
دوره 4 2 شماره
صفحات -
تاریخ انتشار 2002